Heart mitral valve disease (MVD) is a terminal illness which may afflict over half of all cavalier King Charles spaniels by the age of 5 years and nearly all Cavaliers by age 10 years. It is CKCSs' leading cause of death.
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- Researchers determine that moderate to severe pulmonary hypertension worsens outcome of dogs with MVD.
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- University of Georgia researchers compare ACE-inhibitors with aldosterone receptor blockers to combat aldosterone breakthrough in MVD-affected dogs.
- Researchers find gene expression of 5-HT2BR is higher in MVD-affected dogs.
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- Japanese research shows pimobendan causes sudden death in end-stage heart failure in mice.
- Mississippi State University surgeons report long-term success of Chiari-like malformation surgeries.
- Flanders, Belgium now requires CM/SM and MVD testing of cavalier breeding stock.
- Scottish researchers identify 591 differentially expressed genes related to MVD in cavaliers.
- Pet MRI & Imaging Services, Purcellville, VA, offers CM/SM mini-scans for $525.00.
- Dr. George Strain finds tympanometry can be recorded in conscious dogs to assist in the evaluation of the middle ear conditions.
- NC State researchers find adding phenobarbital and bromide increases Levetiracetam's movement through epileptic dogs.
- Ukrainian researchers opine that the small dog genes IGF1 and/or STC2 relate to MVD in cavaliers.
- Swedish study finds serotonin levels increase in spayed bitches.
- German cardiologist examines serum MicroRNAs as diagnostic markers for mitral valve disease.
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- UK's Royal Veterinary College's research team finds levetiracetam to effectively reduce epileptic seizures.
- Dr. Penny Watson discusses the "serotonin connection" between pancreatitis, mitral valve disease, syringomyelia, and other CKCS disorders.
- Korean researchers find link between advanced MVD and pancreatitis.
- "Pancreatitis in Cavaliers: What is it and what can I do about it?" DVD by Dr. Penny Watson.
- UK's Royal Veterinary College's new Epilepsy & Stress study needs affected dogs.
- Idexx Labs announces new early test -- SDMA -- for chronic kidney disease.
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- Infiniti Medical reports successful results of 6-month trial of its Mitrex mitral valve implant device.
- Research shows limited genetic divergence between dog breeds in UK and South Africa.
- Echocardiographic measures of mitral regurgitation severity and mitral valve pathology enable researchers to reliably predict mortality.
- Scandinavian cardiologists find that increased left heart size can predict the risk of congestive heart failure in CKCSs.
- Penn Vet's Dr. Oyama seeks serotonin-blocking drug to stop MVD before heart failure.
- Japanese researchers find post-operative injection of lupeol eliminated recurrence of oral melanoma in a CKCS.
- USA researchers find a new therapy which restores light sensitivity to retina of dogs blinded by retinal atrophy.
- New drug lets paralyzed rats move after spinal cord injuries.
- UK researchers find asymptomatic cavaliers with a syrinx appear more likely to display clinical signs later in life than those without.
- Belgian researchers find no significant difference between CT scans and MRI scans detecting Chiari-like malformation in cavaliers.
- UK Prof. Corcoran reports to UK's cavalier club on current mitral valve disease research.
- Infrared imaging study finds 90% success in identifying dogs with Type I intervertebral disk disease.
- Colin Driver joins the UK's Canine Chiari and Syringomyelia Research Group.
- Ceva's troubling medical treatment study of unsuspecting MVD-affected dogs in heart failure.
- Tufts University's vet school seeks healthy CKCSs for muscle mass clinical trial.
- UK surgeons report limited success inserting tracheal stents for temporary tracheostomies in three brachycephalic cavaliers.
- UK researchers find oral phenobarbital, imepitoin, potassium bromide, and levetiracetam likely are effective to treat idiopathic epilepsy, with a big BUT.
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- Japanese veterinary heart surgeon summarizes current methods of canine mitral valve repairs.
- Syringomyelia in South African cavaliers is 41%.
- Veterinary cardiologist Mark Kittleson dumps on EPIC Trial -- says it has a 50-50 chance.
- Japanese researchers find left atrial enlargement and function correlate with prognosis of early death of MVD dogs.
- Three definitions of Chiari-like malformation are compared in asymptomatic non-CKCS dogs.
- OUR BLOG: So your cavalier has a heart murmur. What do you do next?
- SM study of all cavaliers registered in Denmark in 2001 shows 15.4% have SM symptoms after age 6 years.
- OUR BLOG: Do MVD-affected cavalier King Charles spaniels really need taurine supplements?
- Joe Wakshlag is making some progress in his education about feeding dogs what they need.
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Veterinary specialists have designed breeding guidelines to eliminate early-onset mitral valve disease in cavalier King Charles spaniels.
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Syringomyelia (SM) is reported to be "very widespread" in the cavalier King Charles spaniel breed. Syringomyelia is a disorder of the brain and spinal cord, which may cause severe head and neck pain and possible paralysis.
- More: CKCS syringomyelia
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Hip dysplasia reportedly afflicts up to one out of every four cavalier King Charles spaniels. It is a genetic disease which can cause the dogs pain and debilitation.
Low blood platelet counts in cavaliers usually are not a health problem. Many veterinarians are misled by low platelet counts to wrongly diagnose anemia or other serious disorders.
The size and shape of its head can cause serious breathing problems for the cavalier King Charles spaniel. Elongated soft palates, stenotic nares, everted laryngeal saccules, and laryngeal collapse are inherited developmental defects in the breed.
Cavalier King Charles spaniels appear predisposed to develop cerebellar infarcts, or strokes.
Cavaliers are predisposed to a form of congenital deafness, which is present at birth, and also to a progressive hereditary hearing loss, which usually begins during puppyhood and worsens, or progresses, until the dog is completely deaf, usually between the ages of three and five years.
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