Heart mitral valve disease (MVD) is a terminal illness which may afflict over half of all cavalier King Charles spaniels by the age of 5 years and nearly all Cavaliers by age 10 years. It is CKCSs' leading cause of death.
- More: Cavalier King Charles spaniel MVD
- Mitral valve disease breeding protocol
- A few words about pimobendan (Vetmedin)
- ACVIM cardiologists consensus statement
- Research news
- Find a cardiologist in the USA and Canada
- November 2017 -- Austrian researchers suspect cavaliers may have an impaired immunity to Pneumocystis infection.
- November 2017 -- UK researchers find phantom scratching in CM/SM cavaliers is due to a large syrinx at the superficial dorsal horn.
- November 2017 -- OUR BLOG: Why are cardiology researchers inventing bogus definitions of species-wide heart enlargement to test risky drugs?
- November 2017 -- USA cardiologists study 247 records of MVD-affected dogs to determine what VHS values also equated to EPIC Study echo criteria.
- November 2017 -- Study of 88 MVD-affected dogs under anesthesia during dental procedures finds no increased risk for complications.
- November 2017 -- NC State study of cavaliers with CM and CM/SM finds phantom scratching most common sign and CM-only dogs showing classic pain signs.
- October 2017 -- USA cardiologists find cavaliers with variant of the angiotensin-converting enzyme (ACE) gene have lower ACE activity reaction to mitral valve disease.
- October 2017 -- Cavalier with facial nerve paralysis is successfully treated with laser treatment at acupuncture points.
- October 2017 -- OUR BLOG: The EPIC Study’s three heart “enlargement” parameters are arbitrary and unsupported by their cited authorities!
- October 2017 -- Colorado cardiologist Jeremy Orr advocates prescribing pimobendan to MVD-affected dogs even without heart enlargement.
- October 2017 -- In a French study of 205 dogs with middle ear disorders, only cavaliers had PSOM.
- October 2017 -- Korean study of echocardiograph measurements and biomarkers lists the most reliable parameters for detecting MVD and heart failure.
- October 2017 -- Cavaliers were at highest risk of severe reaction to incompatible blood transfusions, in Italian study.
- October 2017 -- The TEST Study finds torasemide is more effective than furosemide in treating MVD-affected dogs in heart failure over a short term.
- September 2017 -- US and Dutch cardiologists measure mitral valve regurgitation using real-time three-dimensional transthoracic echocardiography (RT3DE).
- September 2017 -- Cardiologists Borgarelli and Menciotti caution against generalizing the narrow EPIC Study results.
- September 2017 -- Polish cardiologists suggest that echocardiography should be used to detect MVD regurgitation which does not produce murmurs.
- September 2017 -- Chiari-like malformation is found in 100% of 1,020 cavaliers in Belgium and the Netherlands and syringomyelia in 39%.
- September 2017 -- PSOM is found in up to 38% of CKCSs examined in a Netherlands/Belgium study of 1,000+ dogs.
- September 2017 -- OUR BLOG: Telemedicine is the answer, when no cardiologist is nearby.
- September 2017 -- OUR BLOG: Cardiac Education Group doubles down on prescribing Vetmedin (pimobendan) to dogs without enlarged hearts.
- September 2017 -- Widespread syringomyelia and craniocervical junction abnormalities are found in study of 53 Chihuahuas.
- August 2017 -- Dr. Martin Schmidt finds cerebral blood flow is reduced in CKCS with ventriculomegaly and may be a form of hydrocephalus.
- August 2017 -- Texas A&M's veterinary cardiology dept. needs young CKCSs for free echo study of healthy mitral valves.
- August 2017 -- University of Minnesota's Canine Genetics Laboratory offers a genetic test for CKCS xanthinuria.
- August 2017 -- French surgeons test an oral approach to installing tympanostomy tubes in cavaliers with PSOM.
- July 2017 -- Neurologist Dr. Coates of Univ. of Missouri needs DM-affected dogs for clinical trial.
- July 2017 -- Spironlactone study of MVD-affected dogs in Stage B2 proves nothing new.
- July 2017 -- Sildenafil (Viagra) beats out enalapril in improving heart rate variability in Stage B MVD-affected dogs.
- July 2017 -- Survey of 339 German cavaliers finds 97.1% with Chiari-like malformation and 48.1% with SM.
- July 2017 -- Cavaliers are found to have significantly flatter tympanic bullae than other brachycephalic breeds -- may explain PSOM.
- July 2017 -- Tufts researchers locate microRNA associated with heart failure in MVD-affected dogs, including cavaliers.
- July 2017: Fortekor Plus (benazepril and pimobendan) passes its marketer's sponsored efficacy test in Stage C MVD-affected dogs.
- July 2017 -- OUR BLOG: The Cardiac Education Group waters down the EPIC Trial recommendations.
- July 2017 -- Dr. Sonya Gordon recommends pimobendan for Stage B dogs even without echocardiograms.
- July 2017 -- OUR BLOG: ACVIM forum Consensus Statement further deteriorates the flawed EPIC Study report.
- June 2017-- ReGena-Vet Laboratories plans stem cell experiments on MVD-affected dogs.
- June 2017 -- German dermatologist successfully treats CM/SM-affected cavaliers for itching with oclacitinib (Apoquel).
- June 2017 -- Ohio State University needs cavaliers for clinical study of syringomyelia.
- June 2017 -- Cavalier breed ranked 4th in number of corneal ulcer cases at the UK primary care clinics in 2013.
- June 2017 -- OUR BLOG: ACKCSC's charitable trust falls for the impossible promised dream.
- June 2017 -- OFA statistics show that hip dysplasia is on a stunning rise in the cavalier King Charles spaniel breed.
- June 2017 -- OUR BLOG: Ten Frequently Asked Questions About Cavaliers and Mitral Valve Disease.
- June 2017 -- OUR BLOG: When should intact cavaliers have a preventative prostate ultrasound?
- June 2017 -- ACE-inhibitor ramipril fails to extend survival times of MVD-affected dogs when combined with pimobendan and diuretic.
- June 2017 -- Italian case study of two CKCSs infected with heartworm Angiostrongylus vasorum brings total to 12 published reports on cavaliers diagnosed with this parasite since 2004.
- June 2017 -- International team of neurologists find cavaliers' gaits may be affected by Chiari-like malformation.
- June 2017 -- Dr. Borgarelli reports successful replacement of mitral valve chords using the Harpoon TSD-5 device.
- June 2017 -- EPIC Study authors plan to announce "longitudinal analysis" of the participating dogs' data.
- June 2017 -- Virginia-Maryland veterinary college creates a database of MVD-affected dogs.
- May 2017 -- Cardiologist Kristin Jacob narrowly interprets the EPIC Study results.
- May 2017 -- Dr. Borgarelli's ongoing mitral valve shape comparison study adds more data.
- May 2017 -- OUR BLOG: EPIC study’s bluster about pimobendan unravels as critical analysis finally takes hold.
- May 2017 -- Cardiologist Mark Rishniw says "Not so fast!" in prescribing pimobendan to all heart-enlarged MVD dogs.
- May 2017 -- Dr. David Williams finds pain from corneal ulceration causes increased tear production and may mask dry eye.
- May 2017 -- Cardiologist Philip Fox claims EPIC Study makes echocardiography optional in prescribing pimobendan before heart failure.
- May 2017 -- Columbian researchers find a variation of gene COL1A2 may play a role in causing MVD in canines.
- May 2017 -- Detroit hospital physicians find Neladenoson may reverse hind leg weakness in dogs in heart failure.
- May 2017 -- Mayo Clinic engineers a designer natriuretic peptide to mediate kidney impairment by furosemide.
- May 2017 -- Synthetic BNP injections potentially can offset RAAS activation in dogs in CHF.
- May 2017 -- Nationwide insurance reports cavaliers and other brachycephalic breeds are more often affected by common health conditions.
Veterinary specialists have designed breeding guidelines to eliminate early-onset mitral valve disease in cavalier King Charles spaniels.
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Syringomyelia (SM) is reported to be "very widespread" in the cavalier King Charles spaniel breed. Syringomyelia is a disorder of the brain and spinal cord, which may cause severe head and neck pain and possible paralysis.
- More: CKCS syringomyelia
- SM breeding protocol
- Research news
- Reduced rate MRI clinic locations
- MRI screening protocol for SM
- Find a neurologist in the USA and Canada
- Use harnesses instead of leashes for CM/SM dogs
- Estimated Breeding Values (EBVs)
- "Pedigree Dogs Exposed"
- "Pedigree Dogs Exposed - Three Years On"
Hip dysplasia reportedly afflicts up to one out of every four cavalier King Charles spaniels. It is a genetic disease which can cause the dogs pain and debilitation.
Low blood platelet counts in cavaliers usually are not a health problem. Many veterinarians are misled by low platelet counts to wrongly diagnose anemia or other serious disorders.
The size and shape of its head can cause serious breathing problems for the cavalier King Charles spaniel. Elongated soft palates, stenotic nares, everted laryngeal saccules, and laryngeal collapse are inherited developmental defects in the breed.
Cavalier King Charles spaniels appear predisposed to develop cerebellar infarcts, or strokes.
Cavaliers are predisposed to a form of congenital deafness, which is present at birth, and also to a progressive hereditary hearing loss, which usually begins during puppyhood and worsens, or progresses, until the dog is completely deaf, usually between the ages of three and five years.
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